Salmonellosis is a disease caused by Salmonella sp., which can cause infections of the digestive tract. Probiotics are good microorganisms that can benefit the host because they can increase the normal flora of bacteria in the digestive tract. They can maintain the intestinal mucosal barrier and prevent bacterial adhesion. The purpose of this study was to determine the histomorphometric characteristics of the jejunum from the intestines of mice (Mus musculus) after being infected with Salmonella sp. A total of 20 mice aged 4-6 weeks were divided into four research groups: P1 (probiotics and Salmonella sp. infection), P2 (probiotic administration), P3 (Salmonella infection only), and P4 (control). The probiotics used contain microorganisms such as Lactobacillus casei, Saccharomyces cerevisiae, and Rhodopseudomonas palustris, dissolved in distilled water in a ratio of 1:1000. Probiotics were given orally for 7 days. Salmonella sp. infection was given orally, with a volume of 0.5 ml (1.5 x 10⁸ CFU/ml). The results showed that the mean score of intestinal lesions was different between groups. The width of the villi, the thickness of the mucosa, and the depth of the intestinal crypts were significantly different. The best histological picture was in the group of mice that induced with probiotics only.