The combination of ketamine-xylazin is one injection anesthetic that is often used in birds. The purpose of this study was to determine the effectiveness of xylazin combination ketamine multilevel dose of drug duration and Lovebird body physiology. The study was conducted on 7 birds with 4-12 months of age and body weight 40-45 grams given 3 treatments of multilevel dose of ketamine injection with a combination of xylazin 10 mg/KgBB on M.Pectoralis. The first treatment ketamine 40 mg / KgBB, the second treatment ketamine 50 mg/KgBB and the third treatment ketamine 60 mg/KgBB. The parameters in this study are the drug onset and duration of anesthesia and physiological responses in the form of heart rate, respiration rate and pain reflexes. Physiological response monitoring is carried out every 10 minutes. Physiological responses are analyzed descriptively. The result shows that the most effective anesthetic combination is Ketamine 60 mg/KgBB-Xylazin 10 mg/KgBB. Both has the fastest onset of action which is 4 minutes with the longest anesthetic duration of 51 minutes and the highest heart rate is 178 bpm and the lowest respiration rate is 46 times per minute, it has the longest anesthetic duration with a stable heart rate and respiration rate.