Septicemic Epizootica (SE) in livestock causes by bacterial infection of Pasteurella multocida. The serotype of P. multocida that causes SE in cattle and buffalo in Indonesia is the Asian serotype B: 2. The objective of this study is to develop of determine antibody responses of cattle after vaccinating with local isolates Local isolate SE Vaccine.  Ten female cattles aged around one year used in this experiment. Cattle divided into 3 groups, Group A (4) vaccinated with local isolates SE vaccines, group B (4) vaccinated with commercial SE vaccines and group C (2) unvaccinated. The concentration of SE vaccine is 2mg, and the vaccine was administrated 3ml sub-cutaneouslly. Antibody responses measured before and after vaccination using indirect-ELISA. The result of antibody response of cattle vaccinated with local isolate SE vaccine in seppic montanide formulation showed higher results compared to SE commercial vaccine and unvaccinated group.

Keywords: Antibody, Cattle, Local isolate, SE, Vaccine.