Plumbum exposure is known can induce excessive production of Reactive Oxygen Species (ROS) and cause oxidative stress on the cell. Oxidative stress can cause disorders of the body's organs, one of which is a liver organ. The study aims to determine the effect of giving red fruit oil as a protection against the exposure of plumbum at the rate degeneration and cell necrosis of liver, red fruit oil has a content of antioxidant compounds beta carotene and tocopherol that function as antidotes to free radicals to prevent oxidative stress from occurring. This study was conducted for 14 days with 4 treatment i.e. P0 (negative control), P1 (positive control given exposure to plumbum at a dose of 0, 01mg), P2 (0.3 ml oil of red fruit and exposure to plumbum at a dose of 0, 01mg) and P3 (0.8 ml of red fruit oil and  exposure to plumbum at a dose of 0, 01mg). Determination of the level of degeneration and necrosis of liver cells is done by looking at the hematoxylin eosin (HE) preparation of mice's liver under the microscope with magnification 400. The results of this study showed that the red fruit oil at a dose of 0, 3ml and 0, 8ml did not give a noticeable effect on the level of degeneration and necrosis of a mice's liver cell compared with positive control that was exposure by plumbum.

Keywords: Degeneration, Mice, Necrosis, Plumbum, Red fruit oil